Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes

URI http://www.lib.tokushima-u.ac.jp/repository/metadata/110843
Title
Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes
Authors
Kamezaki, Chihiro
Nakashima, Ami
Yamada, Asako
Uenishi, Sachiko
Ishibashi, Hiroshi
Shibuya, Natsumi
Hama, Susumu
Hosoi, Shinzo
Yamashita, Eiji
Kogure, Kentaro
Authors_Transcription
カメザキ, チヒロ
ナカシマ, アミ
ヤマダ, アサコ
ウエニシ, サチコ
イシバシ, ヒロシ
シブヤ, ナツミ
ハマ, ススム
ホソイ, シンゾウ
ヤマシタ, エイジ
コグレ, ケンタロウ
Authors_Alternative
小暮, 健太朗
Authors_Affiliation
Kyoto Pharmaceutical University
AstaReal Co., Ltd.
Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences, Tokushima University, Graduate School
Keywords
astaxanthin
vitamin E
tocotrienol
intermolecular interaction
synergistic activity
Description

Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro. Liposomes co-encapsulating astaxanthin and α-T showed no additive anntioxidative effect, while the actual scavenging activity of liposomes co-encapsulating astaxanthin and T3 was higher than the calculated additive activity. To clarify why this synergistic effect occurs, the most stable structure of astaxanthin in the presence of α-T or α-T3 was calculated. Only α-T3 was predicted to form hydrogen bonding with astaxanthin, and the astaxanthin polyene chain would partially interact with the α-T3 triene chain, which could explain why there was a synergistic effect between astaxanthin and T3 but not α-T. In conclusion, co-encapsulation of astaxanthin and T3 induces synergistic scavenging activity by intermolecular interactions between the two antioxidants.

Publisher
Society for Free Radical Research Japan
Content Type
学術雑誌論文
ISSN・ISBN
09120009
18805086
NCID
AA10710201
AA12091064
Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume
59
ISSUE
2
SPage
100
EPage
106
Published Date
2016-09-01
remark

© 2016 Society for Free Radical Research Japan

edb id
317555
URL ( Publisher's Version )
set
徳島大学
FullText URL
Language
eng
TextVersion
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